Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3626 PA1074 branched-chain amino acid ABC transporter substrate-binding protein BraC braC, PA1074 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015803The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. GO:0042941The process in which D-alanine, the D-enantiomer of 2-aminopropanoic acid, is transported across a lipid bilayer, from one side of a membrane to the other by means of some agent such as a transporter or pore. +710 total
0.655 No Hit N/A —
3627 PA5011 heptosyltransferase I rfaC, waaC, PA5011 AlphaFold
2.4.99.23
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008713Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. +47 total
0.654 No Hit N/A —
3628 PA4552 type 4 fimbrial biogenesis protein PilW pilW, PA4552 AlphaFold –
GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0043683The assembly from its constituent parts of a type IV pilus. +14 total
0.654 No Hit N/A —
3629 PA3537 ornithine carbamoyltransferase PA3537, argF AlphaFold
2.1.3.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0004585Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. +58 total
0.654 Hit 43.8% 2.89e-75
3630 PA2437 hypothetical protein PA2437 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.654 No Hit N/A —
3631 PA2293 hypothetical protein PA2293 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.654 No Hit N/A —
3632 PA1458 two-component sensor cheA_4, cheA, PA1458 AlphaFold
2.7.13.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +69 total
0.654 No Hit N/A —
3633 PA5025 O-acetylhomoserine aminocarboxypropyltransferase PA5025, metY AlphaFold –
GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0071269The chemical reactions and pathways resulting in the formation of L-homocysteine. +47 total
0.653 Hit 35.9% 1.34e-62
3634 PA4031 inorganic pyrophosphatase ppa, PA4031 Experimental + AlphaFold
3.6.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0004427Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. +36 total
0.653 Hit 32.4% 1.50e-06
3635 PA3466 ATP-dependent RNA helicase PA3466 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
0.653 Hit 56.4% 4.84e-07
3636 PA1347 transcriptional regulator PA1347 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.653 No Hit N/A —
3637 PA0797 transcriptional regulator PA0797 Experimental + AlphaFold –
GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046872Binding to a metal ion. +14 total
0.653 No Hit N/A —
3638 PA4972 hypothetical protein PA4972 Experimental + AlphaFold – – 0.652 No Hit N/A —
3639 PA4752 cell division protein FtsJ rlmE, rrmJ, PA4752, ftsJ AlphaFold
2.1.1.166
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008650Catalysis of the reaction: a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H+. GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. +25 total
0.652 Hit 47.2% 7.98e-20
3640 PA4560 isoleucine--tRNA ligase ileS, PA4560 AlphaFold
6.1.1.5
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +710 total
0.652 Hit 35.7% 0.00e+00
3641 PA3170 N-ethylammeline chlorohydrolase PA3170 Experimental + AlphaFold –
GO:0090614Catalysis of the reaction: S-methyl-5'-thioadenosine + H2O + H+ = S-methyl-5'-thioinosine + NH4+. GO:0004000Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R). +36 total
0.652 Hit 29.4% 3.54e-13
3642 PA3064 hypothetical protein pelA, PA3064 Experimental + AlphaFold –
GO:0019213Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. +14 total
0.652 No Hit N/A —
3643 PA2772 hypothetical protein PA2772 AlphaFold – – 0.652 No Hit N/A —
3644 PA2116 hypothetical protein PA2116 AlphaFold
4.2.1.-
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.652 Hit 32.2% 5.27e-06
3645 PA4976 arginine:pyruvate transaminase AruH aruH, PA4976 AlphaFold
2.6.1.84
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +36 total
0.651 Hit 33.3% 8.38e-32
3646 PA4825 Mg(2+) transport ATPase mgtA, PA4825 AlphaFold
7.2.2.14
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +69 total
0.651 Hit 37.0% 2.85e-07
3647 PA3910 extracelullar DNA degradation protein EddA eddA, PA3910 AlphaFold – – 0.651 No Hit N/A —
3648 PA3785 hypothetical protein PA3785 AlphaFold – – 0.651 No Hit N/A —
3649 PA3467 major facilitator superfamily transporter PA3467 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.651 Hit 32.8% 6.96e-07
3650 PA3294 hypothetical protein PA3294 AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033104A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. GO:0033103The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.
0.651 No Hit N/A —
Page of 223 · 5572 total proteins