Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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62 / 62 proteins

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Sorted by Human off-target (ascending)

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 HT085_RS00020 hypothetical protein AlphaFold DB model – – No map No pocket No Hit — —
27 HT085_RS00035 DpnI domain-containing protein dpnC AlphaFold DB model – – No map No pocket No Hit — —
28 HT085_RS00060 helix-turn-helix domain-containing protein ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map No pocket No Hit — —
29 HT085_RS00080 preprotein translocase subunit SecG secG AlphaFold DB model –
GO:0009306The controlled release of proteins from a cell. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map No pocket No Hit — —
30 HT085_RS00090 GAF domain-containing protein ytsP, msrC AlphaFold DB model
1.8.4.14
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.
No map No pocket No Hit — —
31 HT085_RS00105 TonB-dependent iron piracy receptor TdfF tdfF ColabFold model – – No map No pocket No Hit — —
32 HT085_RS00110 cupin domain-containing protein AlphaFold DB model – – No map No pocket No Hit — —
33 HT085_RS00115 siderophore ABC transporter substrate-binding protein AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map No pocket No Hit — —
34 HT085_RS00120 helix-turn-helix transcriptional regulator ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map No pocket No Hit — —
35 HT085_RS00130 amino-acid N-acetyltransferase argA AlphaFold DB model
2.3.1.1
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +14 total
No map No pocket No Hit — —
36 HT085_RS00135 MJ0042-type zinc finger domain-containing protein AlphaFold DB model – – No map No pocket No Hit — —
37 HT085_RS00145 uracil-DNA glycosylase family protein AlphaFold DB model – – No map No pocket No Hit — —
38 HT085_RS00150 ribosomal protein S18-alanine N-acetyltransferase rimI ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map No pocket No Hit — —
39 HT085_RS00155 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB tsaB, yeaZ AlphaFold DB model –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map No pocket No Hit — —
40 HT085_RS00160 factor H-binding protein ColabFold model – – No map No pocket No Hit — —
41 HT085_RS00165 class II fructose-bisphosphate aldolase fda, fba Experimental + AlphaFold DB model
4.1.2.13
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
No map No pocket No Hit — —
42 HT085_RS00170 tyrosine recombinase XerC xerC AlphaFold DB model –
GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map No pocket No Hit — —
43 HT085_RS00180 hypothetical protein ColabFold model – – No map No pocket No Hit — —
44 HT085_RS00235 hypothetical protein AlphaFold DB model – – No map No pocket No Hit — —
45 HT085_RS00240 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA queA AlphaFold DB model
2.4.99.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051075Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No map No pocket No Hit — —
46 HT085_RS00250 hypothetical protein AlphaFold DB model – – No map No pocket No Hit — —
47 HT085_RS00255 ComF family protein AlphaFold DB model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map No pocket No Hit — —
48 HT085_RS00260 endonuclease domain-containing protein Experimental + AlphaFold DB model – – No map No pocket No Hit — —
49 HT085_RS00275 PilC family type IV pilus tip adhesin pilC ColabFold model – – No map No pocket No Hit — —
50 HT085_RS00290 protein disulfide oxidoreductase resA_1, resA_3 AlphaFold DB model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
No map No pocket No Hit — —
Page of 3 · 62 total proteins