Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
701 / 5572 proteins Structure: Experimental

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: Experimental

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 PA0845 neutral ceramidase PA0845 Experimental + AlphaFold DB model
3.5.1.23
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. +58 total
No map 0.919 Hit 36.1% 3.16e-129
52 PA0388 hypothetical protein PA0388 Experimental + AlphaFold DB model – – No map 0.919 No Hit N/A —
53 PA4411 UDP-N-acetylmuramate--L-alanine ligase PA4411, murC Experimental + AlphaFold DB model
6.3.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008763Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine. +69 total
No map 0.918 No Hit N/A —
54 PA4310 chemotactic transducer PctB PA4310, pctB Experimental + AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0006935The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). +36 total
No map 0.918 No Hit N/A —
55 PA0518 cytochrome C-551 PA0518, nirM Experimental + AlphaFold DB model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +14 total
No map 0.917 No Hit N/A —
56 PA3270 hypothetical protein PA3270 Experimental + AlphaFold DB model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.915 No Hit N/A —
57 PA0086 hypothetical protein tagJ, PA0086 Experimental + AlphaFold DB model –
GO:0005515Binding to a protein.
No map 0.915 No Hit N/A —
58 PA0962 DNA-binding stress protein PA0962 Experimental + AlphaFold DB model –
GO:1990084A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0008199Binding to a ferric iron ion, Fe(III). +25 total
No map 0.914 No Hit N/A —
59 PA3518 hypothetical protein PA3518 Experimental + AlphaFold DB model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0046872Binding to a metal ion. +14 total
No map 0.913 No Hit N/A —
60 PA4601 motility regulator PA4601, morA Experimental + AlphaFold DB model
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. +710 total
No map 0.912 No Hit N/A —
61 PA0985 pyocin S5 PA0985, pyoS5 Experimental + AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. GO:0140911An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death. +25 total
No map 0.912 No Hit N/A —
62 PA5112 esterase estA, PA5112, papA Experimental + AlphaFold DB model
3.1.1.1
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0106435Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. +912 total
No map 0.911 No Hit N/A —
63 PA3787 hypothetical protein PA3787 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
No map 0.911 No Hit N/A —
64 PA3588 porin PA3588 Experimental + AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
No map 0.909 No Hit N/A —
65 PA0427 outer membrane protein OprM oprM, oprK, PA0427 Experimental + AlphaFold DB model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
No map 0.909 No Hit N/A —
66 PA4410 D-alanine--D-alanine ligase ddlB, PA4410 Experimental + AlphaFold DB model
6.3.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008716Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate. +58 total
No map 0.908 Hit 24.3% 9.48e-06
67 PA3004 S-methyl-5'-thioinosine phosphorylase PA3004 Experimental + AlphaFold DB model
2.4.2.44
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0017061Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. +47 total
No map 0.908 Hit 40.4% 2.25e-07
68 PA2196 transcriptional regulator PA2196 Experimental + AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.907 No Hit N/A —
69 PA4876 OsmE family transcriptional regulator PA4876, osmE Experimental + AlphaFold DB model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
No map 0.906 No Hit N/A —
70 PA3967 hypothetical protein PA3967 Experimental + AlphaFold DB model –
GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872Binding to a metal ion. GO:0019825Binding to oxygen (O2). +14 total
No map 0.906 No Hit N/A —
71 PA4265 elongation factor Tu PA4277, tufA, tufB Experimental + AlphaFold DB model –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. +14 total
No map 0.905 Hit 81.8% 1.19e-10
72 PA5484 two-component sensor PA5484 Experimental + AlphaFold DB model
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +58 total
No map 0.904 No Hit N/A —
73 PA1358 hypothetical protein PA1358 Experimental + AlphaFold DB model – – No map 0.904 No Hit N/A —
74 PA3649 zinc metalloprotease mucP, PA3649 Experimental + AlphaFold DB model
3.4.24.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0046872Binding to a metal ion. +47 total
No map 0.903 No Hit N/A —
75 PA3133 transcriptional regulator PA3133 Experimental + AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0048023Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin.
No map 0.903 No Hit N/A —
Page of 29 · 701 total proteins