Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3326 PA5091 N-formylglutamate amidohydrolase PA5091, hutG AlphaFold
3.5.1.68
GO:0050129Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate. GO:0006548The chemical reactions and pathways resulting in the breakdown of L-histidine. GO:0019556OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-histidine into other compounds, including glutamate and formamide. +14 total
No map 0.686 No Hit N/A —
3327 PA3329 hypothetical protein PA3329 Experimental + AlphaFold
2.3.1.282
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.686 No Hit N/A —
3328 PA3232 DNA polymerase III subunit epsilon PA3232 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003676Binding to a nucleic acid. +14 total
No map 0.686 No Hit N/A —
3329 PA1311 phosphonoacetaldehyde hydrolase phnX, PA1311 AlphaFold
3.11.1.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. +36 total
No map 0.686 No Hit N/A —
3330 PA0793 hypothetical protein PA0793 Experimental + AlphaFold –
GO:0016863Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. GO:0019629OBSOLETE. The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
No map 0.686 No Hit N/A —
3331 PA0608 phosphoglycolate phosphatase PA0608, gph1 AlphaFold
3.1.3.18
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. GO:0008967Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. +36 total
No map 0.686 No Hit N/A —
3332 PA0296 glutamine synthetase spuI, PA0296 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0006542OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. +58 total
No map 0.686 Hit 24.2% 3.59e-29
3333 PA5428 transcriptional regulator PA5428 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.685 No Hit N/A —
3334 PA5419 sarcosine oxidase subunit gamma soxG, PA5419 AlphaFold –
GO:0008115Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2. GO:1901053OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sarcosine. GO:0005515Binding to a protein.
No map 0.685 No Hit N/A —
3335 PA4963 hypothetical protein PA4963 AlphaFold – – No map 0.685 No Hit N/A —
3336 PA4412 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase PA4412, murG Experimental + AlphaFold
2.4.1.227
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051991Catalysis of the reaction: di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H+ + UDP. GO:0050511Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamm-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H+ + UDP. +710 total
No map 0.685 No Hit N/A —
3337 PA3296 alkaline phosphatase phoA, PA3296 AlphaFold
3.1.3.1
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004035Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. +47 total
No map 0.685 Hit 29.2% 7.86e-35
3338 PA0896 arginine N-succinyltransferase subunit alpha PA0896, astA, aruF Experimental + AlphaFold
2.3.1.109
GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +14 total
No map 0.685 No Hit N/A —
3339 PA0236 transcriptional regulator PA0236 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.685 No Hit N/A —
3340 PA4850 50S ribosomal protein L11 methyltransferase prmA, PA4850 AlphaFold
2.1.1.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016279Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. GO:0032259The process in which a methyl group is covalently attached to a molecule. +25 total
No map 0.684 Hit 31.2% 1.11e-06
3341 PA4724.1 hypothetical protein AlphaFold – – No map 0.684 No Hit N/A —
3342 PA4682 hypothetical protein PA4682 AlphaFold – – No map 0.684 No Hit N/A —
3343 PA4508 transcriptional regulator PA4508 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.684 No Hit N/A —
3344 PA4236 catalase katA, PA4236 Experimental + AlphaFold
1.11.1.6
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004096Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +47 total
No map 0.684 Hit 65.5% 6.07e-06
3345 PA4226 dihydroaeruginoic acid synthetase pchE, PA4226 AlphaFold
6.2.1.69
GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. +36 total
No map 0.684 Hit 39.1% 6.11e-08
3346 PA3611 hypothetical protein PA3611 Experimental + AlphaFold – – No map 0.684 No Hit N/A —
3347 PA3441 molybdopterin-binding protein PA3441 AlphaFold –
GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
No map 0.684 No Hit N/A —
3348 PA3094 transcriptional regulator PA3094 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.684 No Hit N/A —
3349 PA2777 hypothetical protein PA2777 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015499Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. GO:0015724The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.684 No Hit N/A —
3350 PA1997 acetoacetyl-CoA synthetase PA1997 AlphaFold –
GO:0030729Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
No map 0.684 Hit 43.1% 0.00e+00
Page of 223 · 5572 total proteins